Boy, time sure has slipped away from me! It’s been almost 9 months since I’ve compiled a list of the latest fibromyalgia- and Lyme-related research studies from ClinicalTrials.gov. I usually try to push out an update every 3 months.
Needless to say there are A LOT of studies that need to be covered – so much so, in fact, that I’m going to split this update into two parts. I’ll post part 1 this week and part 2 next week.
Because it’s been so long since I’ve done an update, we have a nice mix of treatment-related fibromyalgia studies, and there are even a couple of studies that are exploring the underlying mechanisms behind fibro symptoms.
Sadly, I can’t say the same for Lyme disease. As usual, there are few studies, and most are aimed at prevention of Lyme (i.e. vaccine candidates) versus treatment for those of us who are living with it. I included 3 Lyme studies below and will have 3-4 more next week, but that’s a mere drop in the bucket, as they say, compared to the number of fibro studies.
After you read through the summaries, let me know in the comments below if you’re excited or hopeful about any of these upcoming studies!
And as usual, if you find this research update helpful, please share it on your social media and with your fellow fibro friends and support groups. Sharing does two things: It provides your fellow fibro warriors with useful information and hope, and it helps to financially support my work here at FedUpWithFatigue.com! Now on with the update…
New fibromyalgia studies…
Dr. Elif Yaksi from Abant Izzet Baysal University in Turkey will “compare the autonomic dysfunction of fibromyalgia patients with healthy volunteers by electrophysiological evaluation and to investigate the relationship between vitamin D levels and inflammatory parameters in fibromyalgia patients and the data obtained from electrophysiological studies. In this way, we aimed to contribute to a better understanding of the physiopathology of fibromyalgia patients with autonomic dysfunction,” according to ClinicalTrials.gov.
During a previous study, researchers from Kaohsiung Medical University Chung-Ho Memorial Hospital in Taiwan “found that excessive LPC16:0 resulting from lipid oxidization inflicts psychological stress-induced chronic non-inflammatory pain via activating ASIC3. In this content, our prior translational research identified a potential nociceptive ligand that causes fibromyalgia symptoms, which is likely to function as biomarkers for diagnosis or disease monitor. In the current clinical investigation, the investigators aim to reversely translate the novel findings in animal studies and validate the bio-significance of LPC16:0 for fibromyalgia with clinical approaches,” reads ClinicalTrials.gov.
(FYI: I promise not all of the descriptions are as technical as this one! I literally had to cut and paste the description verbatim because I, myself, do not quite understand exactly what they’re doing but it sounds promising!)
About 460 fibromyalgia patients will take part in a randomized, double-blind, placebo-controlled 16-week study to evaluate the safety and efficacy of IMC-1, an antiviral/anti-inflammatory drug combination.
This study out of Frederiksberg University Hospital in Spain will help determine if cannabidiol (i.e. CBD) improves pain, sleep, quality of life and overall functioning among 200 fibromyalgia patients.
(Read more: What you need to know about CBD oil and fibromyalgia)
(Read more: How to use medical marijuana without getting high)
(Read more: How to choose hemp CBD oil)
Spanish researchers from Fundació Sant Joan de Déu will “evaluate the effectiveness and safety of LDN [low dose naltrexone] in patients with fibromyalgia and analyze its cost-utility both from the government and the healthcare perspective at 12 months follow-up. Brain metabolites and systemic inflammatory biomarkers will be included to evaluate neurobiological mechanisms behind LDN’s therapeutic effects,” according to ClinicalTrials.gov.
(Read more: My LDN story)
(Read more: My friend Janice’s LDN story)
Massachusetts General Hospital will enroll around 60 fibromyalgia patients in hopes of determining if transcutaneous electrical nerve stimulation (TENS) can reduce pain.
(Read more: 6 pain relief devices for fibromyalgia)
This study by Professor Kathleen Sluka from the University of Iowa seeks to determine if adding TENS to routine physical therapy improves fibromyalgia symptoms, increases adherence to physical therapy and reduces medication use.
Duke University researchers will determine if the Sana device, which delivers audio-visual stimulation using coordinated pulses of light through closed eyelids and sound at various frequencies, improves fibromyalgia symptoms.
(Read more: What is the Sana device?)
Mayo Clinic is evaluating if mindfulness techniques reduce fibromyalgia pain.
(Read more: How mindfulness can ease your chronic pain)
During this Turkish study from Ahi Evran University Education and Research Hospital, about 50 rheumatoid arthritis patients will be evaluated for the presence of secondary fibromyalgia and how it’s affected their quality of life.
Multiple healthcare centers in France will assess the prevalence of sleep disorders among fibromyalgia patients.
Researchers from the University of Aberdeen in Scotland will explore “how health and social care for people with fibromyalgia living in the U.K. is organized and delivered” and will “identify models of practice to inform [a] co-design of new care pathways,” reads ClinicalTrials.gov.
Researchers from Aarhus University in Denmark will study the “acceptability and potential effect of a 14 week, 11-module, therapist-assisted, Internet-delivered treatment program [called] ‘One step at the time’ for patients moderately affected by Bodily Distress Syndrome,” according to ClinicalTrials.gov.
Note: This is the first time I’ve seen “bodily distress syndrome” mentioned in relation to fibromyalgia. Click here if you’d like to learn more about this new diagnosis.
Turkish researchers from Yerkoy State Hospital will compare the incidence of temporomandibular disorders (i.e. TMJ/jaw pain) among 150 women with fibromyalgia and 150 health controls.
In this small study (30 patients), Camilo Jose Cela University researchers in Spain are studying if manual lymphatic drainage can decrease fibromyalgia pain.
About 1,000 patients with chronic widespread pain (including fibromyalgia) will participate in a study at Frederiksberg University Hospital in Denmark in an attempt to identify “prognostic factors” that predict which patients will leave employment due to disability.
Pediatric patients with chronic widespread pain (including fibromyalgia) will participate in an exercise program with the following goals: “(1) To understand how thermal pain sensitivity, pain symptoms and motor performance are impacted in patients with chronic pain after an exercise-based intervention. (2) To evaluate the brain regions involved in a simple motor task as well as how motor activity influences activity in pain regions of the brain. (3) To evaluate the network structure of the brain, with special emphasis on motor and pain regions, in youth with a pain disorder who have undergone an exercise-based intervention,” according to ClinicalTrials.gov.
Turkish researchers from Bozyaka Training and Research Hospital will assess the relationship between kinesiophobia, (i.e. fear/avoidance of physical activity), and cognitive functions, disease severity, quality of life, physical activity level, pain intensity and anxiety/depression levels in fibromyalgia patients. Additionally, the investigators will compare the kinesiophobia level and cognitive functions between patients with fibromyalgia syndrome and healthy controls.
The goal of this study by researcher Manuel Rebollo Salas from the University of Seville in Spain “is to get to know if applying both pain neuroscience education plus strength training will reduce the pain of fibromyalgia. Both therapies have shown evidence of improvement in fibromyalgia patients. However, there are no studies evaluating their efficacy in combination,” reads ClinicalTrials.gov.
This study by Dr. Mustafa Yilmaz at Istanbul University-Cerrahpasa in Turkey will compare aerobic exercises versus postural stabilization exercises in fibromyalgia patients.
Lyme Disease Studies…
This small study (15 patients) out of Stanford University will determine if 12 weeks of online yoga classes improves chronic pain associated with Lyme disease.
MassBiologics, the only nonprofit, FDA-licensed manufacturer of vaccines in the United States, will investigate the safety and tolerability of 2217LS, a human antibody that’s designed to protect against Lyme disease in healthy people.
Researchers from University Hospital in Strasbourg, France, will investigate the potential of a new diagnostic method for identifying Lyme bacteria using the skin and possibly the synovial fluid and cerebrospinal fluid.