23 clinically-proven ways to reduce fibromyalgia fatigue

This article on “23 clinically-proven ways to reduce fibromyalgia fatigue” was originally published on NationalPainReport.com. It is being republished here with permission from the editor. 

23 clinically-proven ways to reduce fibromyalgia fatigue | Fed Up with Fatigue

A few weeks ago, I had a reader point out that I write a lot about relieving fibromyalgia pain, but very little about reducing fatigue. Well, there’s a reason for that: There always seem to be far more options for pain management than fatigue.

But my reader’s comment got me curious about the research regarding fibromyalgia and fatigue. I wondered if there is anything clinically proven to actually relieve fibro fatigue. I searched PubMed and found a couple of fairly recent (2013 and 2016) meta-analyses that reviewed treatment options for fibromyalgia fatigue. From those, I’ve compiled the following list of treatments, which are supported by clinical trials and can be used as a starting point for your own research. I’ve also included at least one resource for each item on the list for those who want to delve a little deeper into a particular treatment.

I’ll warn you that some of the items on the list are the same old-same old that physicians have been pushing on us for years, but there are many others that I didn’t know about and may be new to you, too.

Also, some of the trials cited involved small numbers of patients. Personally, small trial numbers don’t bother me, but I understand that some readers may question the effectiveness of certain treatments based on such limited data. That’s understandable; I am simply compiling and presenting the data for you. How you perceive it and/or use it is up to you.

And finally, this list wasn’t written with entertainment in mind, so please forgive the overuse of wording like “a small study found…” and “[fill in the blank with any treatment] reduced fatigue…” Yes, I know the wording on the list is redundant, but there are only so many ways to essentially say the same thing.

So, without further delay, here is my list of 23 clinically-proven ways to reduce fibromyalgia fatigue:

1. Aerobic exercise

Yep, you knew this would be on the list, didn’t you? A 2010 meta-analysis involving almost 2,500 fibromyalgia patients found that aerobic exercise improved their pain, fatigue, depressed mood and overall quality of life. The analysis looked at land-based versus water-based forms of exercise, but did not find one superior over the other.

The German researchers concluded, “The amount and intensity of initial AE [aerobic exercise] should be adapted to the individual level of physical fitness. Patients should start at levels just below their capacity and gradually increase the duration and intensity until they are exercising with low to moderate intensity for 20 to 30 minutes 2 to 3 times/week. … Patients should be educated that they may have some tolerable short-term increases in pain and fatigue but, if they exercise at an appropriate intensity, these symptoms should return to baseline levels within the first few weeks of exercise.”

In other words, start low and go slow, but expect to feel worse before you feel better.

Frida Center for Fibromyalgia: Intro to Fibromyalgia Exercise (video, 2 minutes) and Warm-Up Exercise for Fibromyalgia (video, 9 minutes)

2. Strength training

A small 2008 Finnish study involving 26 post-menopausal women with fibromyalgia found that concurrent strength and endurance training improved fatigue, but researchers added that more studies need to be conducted to confirm the results. A similar study involving pre-menopausal women also supported improvements in fatigue levels.

National Fibromyalgia Association: Strength Training for the Person with Fibromyalgia (article)

3. Yoga

A 2013 meta-analysis with 300+ fibromyalgia patients looked at various forms of meditative movement, such as tai chi, qigong, etc., and found that only yoga was beneficial in relieving fibromyalgia fatigue. Yoga also improved pain and depression.

Aroga Yoga: Yoga Sequence for Chronic Illness (video, 22 minutes)

4. Whole-body vibration exercise

A small Spanish study using traditional exercise in tandem with whole-body vibration exercise led to reduced fatigue.

Cochran Library: Whole Body Vibration Exercise for Fibromyalgia (article)

5. Balneotherapy

Join any fibromyalgia support group, and chances are many of its members will recommend Epsom salt baths for pain reduction. Well, it turns out my fellow fibro warriors are onto something! At least three research studies (20012004 and 2005) using mineral-rich baths, or balneotherapy, as a treatment for fibromyalgia reported an improvement in fatigue.

Balneotherapy Association of North America: North American Waters (article)

Spa Index: 30 Favorite Hot Springs and Mineral Springs (article)

6. Sleep hygiene

Fatigue, pain and sleep quality all improved when fibromyalgia patients followed certain sleep hygiene guidelines as part of a 2012 Brazilian study.

“Sleep hygiene instructions include advice to have regular sleeping routines; avoid coffee, tea, food, alcohol, smoking and watching TV close to bedtime; regulate the sleeping environment, such as having a comfortable bed and optimal room temperature; avoid light and loud noise and be regularly physically active, however, not too close to bedtime,” read a 2016 Swedish meta-analysis.

American Sleep Association: Top Sleep Hygiene Tips (PDF)

7. Raw vegetarian diet

Broccoli lovers rejoice! Eating a mostly raw vegetarian diet was found to improve fatigue in a small study involving 30 fibromyalgia patients.

Everyday Health: Diet Cures for Fibromyalgia – Do They Work? (article)


TENS (transcutaneous electrical nerve stimulation) units have been a staple in fibromyalgia patients’ pain-fighting arsenal for many years, but a small Brazilian study found these inexpensive, over-the-counter devices can also relieve fatigue.

VeryWell: TENS Unit for Fibromyalgia Pain (article)

9. Transcranial magnetic stimulation

Fibromyalgia patients in two small studies (2007 and 2011) reported reduced fatigue after receiving transcranial magnetic stimulation.

HealthRising: Zapping Your Pain Away – Is Transcranial Magnetic Stimulation the Future of Pain Relief for Fibromyalgia and ME/CFS? (article)

10. Electroconvulsive therapy

An extremely small Finnish study involving 13 patients found electroconvulsive therapy improved fatigue and depression from fibromyalgia.

Health.com: 10 Myths and Facts about Shock Therapy (article)

Healthline: Electroconvulsive Therapy Overview (article)

11. Noninvasive cortical electrostimulation

A 2012 study involving 39 fibromyalgia patients and 38 healthy controls found moderate improvement in fibromyalgia fatigue using noninvasive cortical electrostimulation. (Say that 10 times fast!)

American College of Rheumatology: Long-Term Outcomes In Fibromyalgia Patients Treated with Cortical Electrostimulation (article)

12. Sensory motor rhythm treatment

Sensory motor rhythm treatment, a form of neurofeedback, was associated with a decrease in fatigue among 18 fibromyalgia patients in a small Turkish study.

Taylor & Francis Online: A Systematic Review of Neurofeedback as a Treatment for Fibromyalgia Syndrome Symptoms (article)

13. Low-energy laser therapy

Studies are mixed on the effectiveness of low-energy laser therapy for fibro fatigue – one study found no improvement while another one did – but it was helpful for reducing other fibromyalgia symptoms.

Pain News Network: Lasers Work for Fibromyalgia But Why So Pricey? (article)

14. Pulsed ultrasound and interferential current

One study found a reduction in morning fatigue using pulsed ultrasound and interferential current.

Fibromyalgia News Today: Ultrasound for Pain Therapy (article)

Prohealth: Ultrasound Therapy for Fibromyalgia and Lyme Disease (article)

15. Duloxetine (Cymbalta)

Two research studies (2008 and 2011) have found duloxetine, an antidepressant commonly prescribed for fibromyalgia, relieves fatigue, but a third study didn’t show any improvement.

Eli Lilly: Cymbalta Medication Guide (PDF)

16. Milnacipran (Savella)

Milnacipran was shown to decrease fatigue during a 2011 Portuguese study, but six other trials found either no improvement or were unable to draw a conclusion one way or another.

Allergan: Savella Medication Guide (PDF)

17. Fluoxetine (Prozac)

“Significant improvement” in fatigue was experienced by 60 fibromyalgia patients taking fluoxetine (Prozac) during a University of Cincinnati Medical Center study. There were also improvements in pain and depression.

U.S. Food and Drug Administration: Prozac Medication Guide (PDF)

18. Gamma-hydroxybutyrate (GHB)/sodium oxybate (Xyrem)

A University of Texas Health Science Center study involving more than 500 patients found that GHB reduced fibro-related pain, fatigue and sleep disturbance. Another second study out of Canada with 300+ fibromyalgia patients also found benefit. Unfortunately, GHB has developed a bad reputation because it’s been dubbed a date rape drug, and few physicians will prescribe it.

U.S. Food and Drug Administration: Xyrem Medication Guide (PDF)

19. Pramipexole (Mirapex)

Fibromyalgia patients in a small Washington state study experienced improvements in pain, fatigue and overall functionality after taking pramipexole (Mirapex), a drug commonly prescribed for Parkinson’s disease and restless leg syndrome. Researchers concluded the drug was “safe and well tolerated.”

Boehringer Ingelheim: About Mirapex (article)

20. Quetiapine (Seroquel)

Fibromyalgia patients in a small Spanish study had a moderate improvement in fatigue and stiffness after taking quetiapine, an antipsychotic medication commonly prescribed for schizophrenia and bipolar disorder. While quetiapine failed its goal of reducing pain, researchers said the drug should be tested in larger trials because early data suggests it could improve overall quality of life for fibromyalgia patients.

U.S. Food and Drug Administration: Seroquel Medication Guide (PDF)

21. Raloxifene (Evista)

A double-blind, randomized Iranian study involving 100 menopausal women with fibromyalgia found that raloxifene, a drug used to prevent osteoporosis and breast cancer, was effective at reducing pain, fatigue, sleep disturbance and tender point count.

U.S. Food and Drug Administration: Evista Medication Guide (PDF)

22. Acetyl l-carnitine

Acetyl L-carnitine, an amino acid available as an over-the-counter supplement, was found to improve general health and mental health (including fatigue) in an Italian study involving 100+ fibromyalgia patients.

HealthRising: Could A Mitochondrial Enhancer Replace Cymbalta in Fibromyalgia?

23. D-ribose

D-ribose, a form of sugar produced naturally by the body and available in supplement form, actually wasn’t included in either of the meta-analyses that I used to compile this list, but I’m adding it to the list because I’ve personally found it to be so helpful for boosting my energy levels. Well-known fibromyalgia specialist Dr. Jacob Teitelbaum has conducted two d-ribose trials involving fibromyalgia and chronic fatigue patients.

In 2006, Teitelbaum conducted a small study with 41 patients with fibromyalgia and/or chronic fatigue syndrome. At the end of the three-week study, approximately 66 percent of patients reported significant improvement while taking d-ribose, with an average increase in energy of 45 percent.

Teitelbaum followed up the pilot study with a larger multicenter study in 2012, involving 257 people who were given d-ribose for fibromyalgia and/or chronic fatigue. The result was an average energy boost of 61 percent among patients.

Smart Publications: D-Ribose is Awesome – An Interview with Dr. Jacob Teitelbaum (This link includes Dr. Teitelbaum’s d-ribose protocol.)

Now it’s your turn: What is your best tool for relieving fibromyalgia fatigue? Please share in the comments!

You might also like…

A few of my favorite things for relieving the pain and fatigue of fibromyalgia.

Tired all the time? D-ribose has been shown to increase energy levels in those with fibromyalgia and ME/CFS. | FedUpwithFatigue.com


  1. PattyS says

    My symptoms of Fibromyalgia that are most concerning is the cognitive problems and the overall stiffness throughout the day. There is a numbness I feel. It’s like a disconnect from current activities. I am like a step behind. Also, the stiffness is affecting my writing. So, I don’t make lists to get things done. I work at things until I get tired then I turn off mentally. I think minimum 3000 mg Vitamin C a day with Vitamin B and D helps a lot. Also, I tall glass of water when I first wake up and a hot cup of green tea after that. Also then either I cold washcloth on my face and then the washcloth with warm water. Then a hot shower while I continuously do light stretching like ballet. This stretching in the shower really helps make the showering not so tiring. Then the only food is a spoon of peanut butter. Then a couple hours later, some protein and fat meal with a little fruit at the end to help with digestion. I have terrible constipation no matter what I do. So, I take 2 colase a day. I also get up and move every hour. Going back to the start of the morning, I have to stretch and move arms, legs, fingers, head, at least a total of 100 times before getting out of bed. I think I discovered that my hips start to hurt if I don’t have enough lift in my shoes. I can’t walk with flat shoes or barefoot. I add the good feet insoles this morning and my back is already better. I feel best if I only eat very small meals, and nothing after 6 pm. Bone broth and collagen tablets help my hair and nails and skin look better. The only prescription med I take is Provigil for alertness in the morning because of sleep apnea and cpap use.

  2. Susan Libby says

    Hi Donna

    New Subscriber, so thanks a bunch for all your hard work.
    Somewhere on this site you had asked for any ideas for new blog subjects.
    So here is one suggestion
    The connection between Fibromyalgia and Sjogrens Syndrome.
    I have both and the similarities between the two are astounding.
    I have recently begun the self experiments with both LDN and CBD, neither of which my PCP knows much about.

  3. Tabitha says

    Hi! Thanks so much for this post! I have been experiencing nearly pre-Cymbalta level fatigue the last few days, and am desperate to find something to help so I can keep my eyes open at work. Something I have found really helps is Cinnamon. You can get it in capsule form, and just one really boosts my energy. Note of caution, though: cinnamon is very effective in helping regulate blood sugar. A friend of mine took two capsules one day and it bottomed his blood sugar out.

    • Donna Gregory/FedUpwithFatigue.com says

      If you’re responding well to cinnamon, I’m wondering if your fatigue might be related to your blood sugar levels. Have you tried a low carb diet like paleo or keto? Those diets are great at stabilizing blood sugar and generally help w/ fatigue. Just an idea.

  4. Hi,
    Hope you are doing well! I am a follower of fedupwithfatigue.com and is pretty interested in submitting a guest post on your website. Can you kindly let me know of the rules for the same?


  5. Rhonda says

    Exercise is the only thing that makes me feel good! I have had fibro. symptoms for YEARS and finally went to my doctor 4 years ago to begin my endless array of test to rule out EVERYTHING before being diagnosed with Fibromyalgia. (NOT ME…that’s not a real thing!) You see, I was (am) VERY active; working full time, teaching aerobics part time, and coaching youth sports. I hit the wall when I became too tired to do the things I enjoyed, so TIRED that I almost feel asleep driving on several occasions. I tried “slowing down” blaming the fatigue on getting older. I cut out a few of my early morning fitness classes, gave up coaching, and tried to get more sleep….all this did was aggravate my symptoms. The pain increased and I became even more fatigued! My doctor started me on Cymbalta, pain got better, still had fatigue but not as bad, however I started to SWEAT A LOT and as an aerobic instructor it was unbearable…. I was drenched by the end of my class. Tried a lower dose but still ringing wet at the end of class (and sweating at random times during the day). So, I’m switching to Lyrica, hoping this helps. I’m afraid of the lack of concentration and confusion it may cause. I am a teacher and tutor high students, lack of concentration and focus is a BIG issue for me. I already have issues with fibro fog, making my tutoring difficult at times. Has anyone had issues with Lyrica. Also, Alzheimers is in my family and do NOT want to increase my chances. Anyone in the same boat??? Thanks in advance for any advice, suggestions… glad to hear others stories and know I’m not alone (although wish for your sake I was)
    I have to admit I’m embarrassed to go to a support group as most of the individuals who know me cannot believe I have fibromyalgia because they see me as this energizer bunny (didn’t know I was that good of an actress) Thanks again for listening

  6. I found out taking high doses of vitamin d (50,000 iu) weekly helped ALL my symptoms of fibromyalgia took a few months to start working and only works as long as I keep taking it this way soon as I stop they all come back my level is probably above 100ng now been using vitamin d for years not sure how it is working but it does and I have it bad I don’t get flares I have it 24/7 with symptoms like breathing problems, burning eyes,
    weakness, burning mouth, brain fog, head and face tension, pain, ringing ears, fatigue, I get this awful feeling running thru my body arms and legs ect hard to explain but its like a burning or like lave flowing thru the veins or a severe fatigue feeling like you have cancer or the flu i deal with this 24/7 too i have so much more symptoms i also have noticed food and drinks and pills make me worst and cause more symptoms like i have some kind of digestive issue done been thru the leakygut theroy nothing helped and it was torture starving myself no way i can be allergic to everythiing not sure how the food triggers some of the symptoms or make them worst but they do i also had cancer when this all started and was losing my grandparents and my dad from it too it was awful you can imagine but i am 5 years cancer free now!! hope this helps someone and hope this disease is more aware of as some doctors don’t believe it exist and tell u it in your head and toss you around while they make money off your sickness while none have helped

  7. Hi,

    I have been diagnosed with fibromyalgia, about three years ago. I feel that I have completely lost my beauty and youth. I am 33 years ago, and I have gained a bunch of weight that I can’t lose. I used to be very fit and healthy and now I can’t even work out because my body swells up and I’m stiff the very next day. Not to mention the incredible and unbearable pain that goes along with everything else. I am so tired all the dam time, I can sleep for hours and hours and still feel like I haven’t slept in days or weeks. I have severe depression not because I have anything bad going on in my life but due to the pain I feel like crying all the time and my mind becomes wired in a depressive state and my mind is always in a fog like as if I have dementia. I don’t know what to do anymore I have been trying everything under the sun to get healthy and stay well. I have been taking Magnesium pill and a zinc pill and they seem to work but if you ever stop the pain comes back with vengeance. If anyone knows what else can be done to be well from this horrible disease please share.

    • Mae Kohu says

      Have you tried floating. Ive been floating once a week for 2 weeks and my essential tremor in my head and tension in neck and shoulders has reduced significantly. Hope u feel well soon…

  8. Mickey Nice says

    I have fibromyalgia but I also have Chronic Fatigue/ME. Exercise becomes problematic with regards to Post External Malaise,

  9. I think I’ll try tai chi to reduce stiffness.

    WebMD: “tai-chi-beats-aerobics-for-fibromyalgia-pain”

  10. Marvelous, what a blog it is! This blog presents helpful facts to us, keep it up.

  11. Allen Swift says

    I am Allen Swift i was diagnosed with fibromyalgia. I have from moderate to severe pain in most parts of my body, been tested for a lot of things and all came back ok. I have had a lot of stomach pain, there was a day i received a message from my old time friend who has been away for many years he told me he heard about my illness and he directed me to Standard Herbs Home and i contacted them and purchased their herbal medicine and followed the instructions after 4 weeks i was cure from fibromyalgia. Thanks to STANDARD HERBS HOME.

    • reenal pratap says

      Where is this place?i have fibtomayalgia and want to be cured please.help me

    • C Danyell Reese says

      In regards to cure statements….I would like a way to verify that the person is an actual person whomever states such and also that the person isn’t an employee or receiving any payments or benefits from the place in which the person who makes such a statement gives.

  12. Stevelyn says

    DHEA has helped me greatly with brain fog. I was to the point where I could not comprehend simple instructions or remember what things where called. It took about three months for me to really see the effects but it works.

  13. Really, really great list, Donna. My story is similar to yours regarding the beginning of my days prior to diagnosis. I was working 7 days a week in a job I loved, and had just moved into a new home. Besides working, I spent endless hours painting, wallpapering, and lots and lots of gardening. At first my family thought I had Lyme disease, but all tests proved otherwise. I have been fighting fibro for almost 19 years now and am finally feeling a little bit of relief. I have stopped the Tramadol for pain, and getting off of the Cymbalta/Duloxetine was the worse. I would adivise anyone who is on this drug to read posts on-line as to the cases that have been filed against the producers of same. They don’t tell you what happens to you when you try to go off of this drug and it is horrible. My next goal is to try and make an escape from Lyrica. I sometimes believe these drugs just make things worse and I am so glad that you are providing us with alternatives. Don’t get me wrong, I still have the pain, and have a few days out of every month when I can’t get out of bed, but it was no different than when I was on the drugs. Thanks for all the help you lend us and I will definitely try the potato juice.

    • Donna Gregory/FedUpwithFatigue.com says

      Hi Pat, thank you for sharing some of your story w/ me. You mentioned your family thought you might have Lyme at some point, but the tests came back negative. I just wanted to make sure you know that standard testing through mainstream labs like Labcorp and Quest only picks up about 50% of Lyme cases. I’ve had the standard testing at least a half dozen times and it’s been negative every single time, even though I’ve tested positive w/ better testing via iGenex and also through live blood testing. I wanted to share this so you know that you could still have Lyme even w/ a negative test. I wrote this post shortly after I was diagnosed last summer to help others w/ fibro get properly tested and evaluated for Lyme: https://fedupwithfatigue.com/lyme-disease-and-fibromyalgia/ You’re welcome to email me or comment here w/ questions. I have lost count of the number of people who have told me they were diagnosed w/ fibro and later found out they have Lyme. Many of them initially had negative tests but better testing picked it up. Since I was diagnosed, I’ve tried very hard to get the message out about the poor testing. I suspect many people w/ fibro have Lyme and don’t know it. 🙁

      • Rita Shaw says

        Donna, i was really interested in yr lyme story..before I was diagnosed with fibro and chronic fatigue, my dr’s were certain I had lyme,in 2008, but the tests were negative?
        I just picked up copies of tests from 2009 for a new dr. And was surprised to see all the lyme reflex- elisa were high positive..but the western igm and igg were negative?.
        I dont know if it means anything but I have all the symptoms..even hormonal ones…I wonder I worked at hospital and caught MRSA badly..maybe abtibotics blunted tests? I dont really know much about lyme. I had anxiety, multi skeleton pain..in joints..brain fatigue.fog.forgetfulness my 3 -f’s lol though I also developed dyslexia #’s and letters?..heat and cold intolerance..another thing they didnt tell me was my tsh was only 0.37 t4 low also? Along with electrolytes low..I could go on forever…is there any free diagnosis genetic testing?
        Because last time I saw a endro cronist my vca IGg and Eb vca IGG were very high also. But couldnt thst be lyme? My liver enzymes fluctuate high to normal quite rountinely. I dont drink.
        Everytime I get a few answers more questions lead me astray?
        I thought a tbi causing anterior pituitary disorder might be at fault. But I wasnt really fatigue and still worked until after mrsa..and then I went camping again..yikes…ty Donna…Rita

        • Donna Gregory/FedUpwithFatigue.com says

          Hi Rita, if your Elisa was positive, then you almost certainly have Lyme. The testing is notoriously bad for giving false negatives. There are several reasons why your western blot may have come back negative even though your Elisa was positive. This article will give you some insight: http://www.tiredoflyme.com/4-reasons-a-lyme-test-will-come-back-negative-even-if-a-person-truly-has-lyme-disease.html
          This is a really good article w/ info on the issues w/ testing, how to get the most accurate testing, etc.: https://fedupwithfatigue.com/lyme-disease-and-fibromyalgia/
          It would be best for you to see a Lyme specialist to be properly evaluated (and treated if you’re diagnosed). Regular conventional doctors will not be of much (if any) help to you b/c most of them don’t believe in chronic Lyme disease, and even if they do, they aren’t knowledgeable enough to treat it. As you mentioned, there is much more going on w/ you (and w/ most Lyme patients) than simple antibiotics can fix. You need a Lyme literate medical doctor who is versed in all of these issues so they can all be addressed. Sometimes Lyme doctors do not practice publicly so it can be hard to find them w/ a simple Google search. Here are a couple ways to find a good Lyme doc in your area:
          1. Google to find your local (or state) Lyme support group, and then contact them and ask for physician recommendations. Often they will actually have a list they can email you. This is the best way to find a good doctor b/c they will always know the most knowledgeable doctors in your area.
          2. See if there’s a Lyme group for your state on Facebook. The members of these will usually know the best Lyme doctors in your area, too.
          2. Check ILADS.org’s doctor referral system, http://ilads.org/ilads_media/physician-referral/
          3. Check LymeDisease.org’s doctor referral system, https://www.lymedisease.org/find-lyme-literate-doctors/
          Here’s a questionnaire that will help you gauge your risk of having Lyme – it was developed by Dr. Richard Horowitz, one of the nation’s top Lyme specialists, and has been validated through research: http://lymeontario.com/wp-content/uploads/2015/03/Horowitz-Questionnaire.pdf
          I hope this helps! You’re welcome to contact me anytime w/ questions.

  14. CURED

    Aiden Lucas
    I was diagnosed with fibromyalgia for 3 years, and it was very painful some days. I was taken methocarbamol to relieve the pain. Sometimes it helps and other days it doesn’t. it was killing me for 3 years, doctor said there was no cure. So I tried to live with it and it wasn’t easy.My childhood friend introduced me to Dr George (Good health herbs home),Dr George fibromyalgia herbal remedy cured me within 6 weeks of usage ,am fibromyalgia free now 100%.

  15. malvika says

    I am 25 years old diagnosed with Fibromyalgia and have been under physiotherapy for over a month now. The exercises tend to increase my pain at times but helps me feel a little better the next day. The doctor gave me a pill which was to help me get a proper sleep – in vain. After taking the tablets at 7 pm I couldn’t sleep till 2 am on most nights. After a lot of research and discussing with my family doctor the only thing that can help is Homeopathic or Ayurvedic treatments. Hope this information helps some of you who are willing to try it to get rid of the pain.

  16. Martha Murphy says

    Fibro moved in following a bout with H1N1 about ten years ago. My PCP took five minutes to say it was Fibro, and Rxed Cymbalta, and sent me to Rheumy. I have added Soma (muscle relaxer) and Xanax. I read, not long after that, in a Fibro chat room about LDN. The young gentleman obtained it from the River Pharmacy in Canada, and titrates it himself. I did the same and have determined I will never be without it. I take the 4.5 ml dose at bedtime, daily. It is VERY inexpensive (about $150/year) and is the best thing I’ve ever done! I also take many nutrients each day. I am now just shy of 76 yrs old, and my main difficulty is determining what is Fibro and what is age when it comes to pain!

  17. Tried about 1/3-1/2 of these, the others aren’t possible for me. Nothing has helped, and while it is frustrating and overwhelming sometimes I really appreciate you taking the time to compile this list and write this blog!

    The more I research the more convinced I am that my case is quite complex, between multiple diagnoses and no doctors are currently connecting the dots quite the way I need to get some pain and exhaustion relief. Hopefully some day!

  18. My name is Karen and I was diagnosed about 15 years ago. I’ve had trouble with my liver, thyroid, adrenals, spleen etc. I take a long list of supplements and I have found tremendous help with freezing cold showers. I know it sounds awful but if you can brave it for about a minute every day it really helps. Also taking MSM really helps with the arthritis. Hope this helps.

  19. Hi Donna,
    Interesting list but seeing exercise first really made me chuckle! Come on we get a work out every morning! Getting out of bed, having a wash and getting dressed is an incredible workout! That’s without my chronic fatigue or sloth days as I call them. I would add using an essential oil diffuser to the list. I’m amazed how good they are for all sorts of uses including helping you relax and sleep and combating chronic fatigue and the dreaded brain fog! It even helps zap airborne bugs, the diffuser is like a super hero to the chronically ill lol!

  20. Great list. I particularly appreciate the focus on non-Rx/natural options.
    I agree that mitochondrial supports such as D-Ribose & CoQ10 are key (I use Ubiquinol, the more active form of CoQ10, since after age 30 our ability to metabolize the CoQ10 drops significantly (progressively).
    I’d also recommend the Wahl’s Diet to rebuild the body’s ability to heal and increase stamina.
    I would LOVE to see a similar list that goes a step further, with resources that specifically address BRAIN FOG. Mine brain fog is partially a cognitive fatigue, and typically follows closely with physical fatigue (so all much of the above list applies)… but there also seems to be an additional layer, as often it is prominent even when I’m physically “OK”. The cognitive cognitive issues for me are by far the worst… Being unable to depend on my brain to maintain my finances, plan a meal & grocery shop, follow a complex conversation socially, read/retain new info and sometimes even drive safely in traffic are by far the most debilitating & isolating symptoms as well. My abilities fluctuate daily & hourly, and anything that sets my health back in general (stressors, infection, over-exertion) plays havoc on my ability to function cognitively. Not knowing when I can expect to function reliably makes it impossible to maintain a social life, much less employment. I live alone… no kids… no energy to date… so it’s isolating effect has quite an impact on me emotionally at times too.
    Any new research/supplements/dietary protocols to help get my brain back would be much appreciated! I am interested in knowing how LDN or similar options my help reverse this over time too. Would love to hear some success stories from those following.

    • Donna Gregory/FedUpwithFatigue.com says

      Thank you for the idea. It’s a good one, and I will put it on my future post ideas list. It’ll be interesting to see if researchers have even begun to address fibro-related brain fog. I don’t recall seeing much research on it.

      Just FYI: If you haven’t already, you might want to ask your physician for a full thyroid panel – not just the TSH test. I’m working w/ an integrative doctor now and he ran some thyroid testing on me and found that my free T3 level was normal but in the lower range of normal. He told me that a low dose of thyroid medication often clears the brain fog in his fibro patients. I added a low dose of T3 hormone last fall, and it has noticeably reduced my brain fog. (Some of it has come back recently for some reason – not sure why – but it’s not to the extent that it was when I started the medication.) When I interviewed Dr. David Brady a few weeks ago, he said thyroid dysfunction is really common among those of us with fibro, but it goes undiagnosed many times b/c doctors are only testing TSH levels, and then some will only treat if levels are in the low range.

      • I finally ran the panel myself last fall, along w labs for Hashimotos & a general autoimmune panel. T3 was barely in range, so doc started me on WP Thyroid (a NDT).
        Good results for a couple months, then leveled off, then diminishing returns last couple months. (I’m told this indicates poor adrenal reserve). Last month I had very painful bout of post-viral thyroiditis, and the inflammation settling in my thyroid ramped up hormone release throwing me into transient hyperthyroid state, so had to quickly taper off, & will retest 6 wks later. Doc was not sure if the NDT itself might not have actually exacerbated the inflammation

        • Donna Gregory/FedUpwithFatigue.com says

          Hey Kelly, I’m glad you shared your experience. It’s similar to my own. I haven’t written about this on my blog yet, but my doctor did thyroid testing on me last fall – not a full panel, but more than the TSH test – and my free T3 was normal but on the lower side of normal. He suggested trying thyroid medication b/c he said it often helps clear the brain fog of his patients with fibro symptoms. I decided to try the medication and it dramatically reduced my brain fog for a while, but I’ve noticed the effect seems to be wearing off. My fog isn’t as bad as it was in the beginning, but I’m not as clear as I was when I started the medication. I’d been wondering why it seemed like the effects of the thyroid medication were wearing off. Your mention of having poor adrenal reserve makes sense to me. I know I have issues w/ my adrenal function based on saliva testing.

    • Jane K. says

      I take Turmeric Curcumin with Bioprene. It helps with pain, cognition support, and SO much more. I would also suggest this:


      It has an approval rating of about 98% by almost 100 verified users.

      Hope this helps!

  21. Dagmar MacQueen says

    I’ve been taking LDN for 9 months and it’s helped my energy levels hugely. Took me several weeks to work up to the optimum dose, 4.5mgs and now I can live a reasonablish life for most of the day as long as I don’t exert myself. I still can’t find any excercise that helps.

    • Donna Gregory/FedUpwithFatigue.com says

      Congratulations! I’m so happy to hear you’re feeling better! LDN is a miracle drug for some people. Thank you for telling me. I always love to hear about LDN success stories!

  22. Great article! I appreciate that you took the time to include evidence based tips! Thanks!

  23. Katrina says

    I’m confused. Why is there a dog on the advert? I was hoping animal therapy was going to be on the list so I could talk my hubby into getting one!!! L

    • Donna Gregory/FedUpwithFatigue.com says

      LOL! I didn’t mean to confuse you. It’s supposed to be a tired, exhausted dog! 🙂 I love animals and often use them for my graphics b/c they’re more fun to look at than people.

  24. Melissa stevens says

    Hi i discovered quite by accident that taking apple cider vinegar is beneficial. I take 2 table spoons in a glass of water once a day. I also have a teaspoon of cumin (spice) once day. I feel more energised and memory and concentration has improved. Also less stiff and sore. I’m taking it for about 2 months now. Thanks.

    • Donna Gregory/FedUpwithFatigue.com says

      Raw apple cider vinegar is great for lots of things! Gut health, blood sugar control, weight loss, etc. It’s not surprising to me that you’re finding it helpful.

    • Catherine says

      My pain doctor, just last week, told me about the possible pain relief (anti-inflammatory) benefits from taking cumin. I’m looking forward to see how it works for me. I figure it can’t hurt to try.

  25. Wow, this is a really interesting list! I was surprised that yoga specifically was found to be effective compared to other mindful movement practices. Same surprise for epsom salt baths which I usually associate with relaxation and bedtime. It’s great to have a list of options to try.
    In addition to acetyl-L-Carnitine and d-ribose, I also take rhodiola, which has been found to generally improve concentration and mental function under stress or fatigue but not specific to FM. I also find CoQ10 helps, I think because it’s supposed to improve mitochondrial function. It’s a shame more supplements aren’t better studied, when they offer a lot of potential in this area. Thanks so much for a great post!

  26. 2 things help me: Epsom Salts baths and Reiki.

  27. Caprice West says

    My name is Caprice and my reason problems with fibromyalgia is all I want to do is sleep and have nothing accomplish. I call out a lot from work cause I don’t want to go. Any advice will be appreciated. Thank you

    • Donna Gregory/FedUpwithFatigue.com says

      Fatigue is a huge issue w/ fibro. I have a lot of days where I feel the same. I’m planning to explore some of the items on the list and see what happens. Maybe something will help!

  28. Thank you for this list!!!

  29. Please don’t ever take Xyrem. It did help me in the short term but caused extreme problems after my Doctor upped my dose. It is a very difficult drug to regulate and very dangerous. It can cause sleep walking and you can lose touch with reality to the point of a psychotic break. It can cause terrible trauma.

    I do believe that a lot of our symptoms are caused by sleep issues. I had a sleep study done and they found that I have sleep fragmention which disrupts the bodies ability to get the healing powers of sleep. I use gaba which is availale over the counter and relaxes me and helps me sleep better.

  30. Jennfer Craine says

    Thank you for researching and creating a list of option to reduce fatigue. I am going to explore the natural options and see what happens. I love reading your posts. You have excellent resources that Fibro Warriors can tap into:).

    • Donna Gregory/FedUpwithFatigue.com says

      Thank you! I hope you find something that works! If you do, be sure to share it w/ me!!!

      • Please Donna ,God bless you and always makes you happy ,safe and disease free because you really awsome woman who trying the best to help people getting rid of those kind of frustrating syndromes. Please Donna ,if there any news about new treatment,supplement or anything help with FM/CFS please tell me on my email:
        I spent thousands of money from this to that to this to that ,travelling looking for any help without any positive results especially in FATIGUE the big devil which destroy ally life my jobs and took me away from everything and even from people ,friends ,family and all aspects in life.

        • Donna Gregory/FedUpwithFatigue.com says

          The best way to stay up to date is to subscribe to my email list. You can do that by entering your email in the form at the top of my blog.

  31. Doreen Luck Salter says

    Excellent list. At least 10 that I have not heard of. Do you have any suggestions on how to find clinical trials?

  32. Thanks for this list!! I am really interested in herbal remedies too, it’s unfortunate we don’t have research for those.
    Another thing I have found really helpful in managing fatigue are 20-30 minute guided meditations (Yoga Nidra, body scans, self hypnosis) it seems to really assist my body to rest while keeping my brain quiet, it helps me get through the long days!

  33. Thank you, Donna.

    I found that soaking in a warm bath with Epsom Salts helped me. I also benefitted from water aerobics, aquacise, and even swimming. The water cushions the impact on tender joints and muscles.

    My ultimate help was a beautiful mind/body/spirit wellness work that helped me to discover and resolve the many unresolved issues in my life that kept resurfacing and contributing to my fibromyalgia which was devastating my life.


  1. […] (Read more: 23 clinically-proven ways to reduce fibromyalgia fatigue) […]

  2. […] 23 clinically-proven ways to reduce fibromyalgia fatigue […]

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