08.30.2016

Proove Fibromyalgia Profile could improve diagnosis, treatment

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This article on the Proove Fibromyalgia Profile was first published on NationalPainReport.com. It is being reprinted here with permission from the editor. 

The new Proove Fibromyalgia Profile can identify a patient’s genetic predisposition to developing the condition and how well they might tolerate common fibro medications.

The new Proove Fibromyalgia Profile …

Proove Biosciences, a California-based firm specializing in pain medicine, has developed a new tool to help physicians better diagnose and treat fibromyalgia.

“The Proove Fibromyalgia Profile is a first-of-its-kind decision-improvement tool that harnesses individualized information to aid in the identification of genetic factors that may contribute to differing clinical pathways behind a fibromyalgia diagnosis and in the customization of personalized treatment,” reads a press release.

Using DNA collected from a cheek swab, the profile analyzes markers from 11 genes that may play a role in the transmission and processing of fibromyalgia pain.

“These variants were chosen based on published associations with various biological pathways underlying fibromyalgia,” explained Svetlana Kantorovich, Proove’s director of clinical and scientific affairs. “These genes provide information about central pain sensitization and the metabolism of pain medication for an individual patient.”

Physicians receive a report that highlights a patient’s genetic predisposition for developing fibromyalgia and clinical recommendations for how a patient is likely to respond to commonly prescribed fibro medications. Medical providers can use these genetic insights to help diagnose and then individualize treatment for fibromyalgia patients.

“The [fibromyalgia profile] promotes evidence-based decision-making and may aid in better diagnostic and treatment strategies,” Kantorovich explained. “Many approaches today are based on trial-and-error – a slow, iterative process that could be eliminated or at least shortened if the physicians had more information up front.”

It often takes years of shuffling from doctor-to-doctor for most fibromyalgia sufferers to finally be diagnosed. Proove’s fibromyalgia profile could shorten that ordeal.

Fibromyalgia patients also are notoriously sensitive to medications and sometimes can’t tolerate commonly prescribed drugs because of side effects. Proove’s fibromyalgia profile uses a patient’s genetic markers to identify which medications are more likely to be tolerated.

“A doctor will generally choose among the arsenal of [drugs] those things that she prefers … those things that have worked best for her patients in the past or maybe she liked a particular drug representative,” Brian Meshkin, Proove’s CEO, explained. “What we are trying to do is change the paradigm. Beyond the doctor’s preference, what are those one, two, three medications that a doctor should prioritize?”

Proove’s ongoing research could be useful in eventually cobbling together the puzzle of what causes fibromyalgia. Early data suggests some cases of fibromyalgia may be linked to serotonin and catecholamine dysregulation, while others may be immunologic in nature.

“We believe there’s going to be different categories of fibromyalgia diagnoses,” Meshkin said. “We continue to research and evaluate, and just like our other profiles, we anticipate continued research that we will be able to use to improve and answer more questions about fibromyalgia.”

Earlier this year, Proove researchers presented the findings of a retrospective analysis to the annual meeting of the American Academy of Pain Medicine, in which two genetic variants – C-reactive protein (CRP) and protein tyrosine phosphatase non-receptor type 11 (PNPN11) – were identified as being associated with an increased risk of developing fibromyalgia.

“CRP is the gene that codes for C-reactive protein, a biomarker for inflammation,” Kantorovich said. “Previous studies that measured CRP levels found that they are higher in fibromyalgia patients than healthy control subjects, giving credence to the role of inflammation in fibromyalgia, which is suspected to be part of the disease’s pathophysiology but is not always evident in clinical exams. The CRP genetic variant that Proove investigated is associated with higher CRP levels as well, supporting the conclusions of previous research studies and providing a potential marker of evaluating fibromyalgia.

“PTPN11 … is a widely expressed protein in the immune system and is involved in stress response and inflammation,” Kantorovich continued. “The association between the PTPN11 genetic variant Proove investigated and fibromyalgia is a novel finding, and may play a yet unexplored role in the inflammatory component of fibromyalgia.”

The Proove Fibromyalgia Profile just became available to patients a few weeks ago and is not covered by most health insurance companies at this time. The list price is $799.

“We have many opportunities, however, to reduce the out-of-pocket cost to the patient, including participation in clinical studies and assistant programs for those in need,” Kantorovich said.

Contact Proove for more information about the opportunities mentioned above or to find a local physician who is using the fibromyalgia profile.

Now it’s your turn! Do you think there’s a genetic component to fibromyalgia? Sound off in the comments below!

Update, August 2017…

Proove has encountered some recent legal troubles. 

You might also like …

Medicare and some private insurers, including Blue Cross Blue Shield, UnitedHealthcare and Aetna, are now paying for the FM/a fibromyalgia test on a case-by-case basis. EpicGenetics, the company that developed the test, offers free assistance to determine if your insurance will cover the test.

University of Alabama at Birmingham's Dr. Jarred Younger is raising funds to open a new center to fast-track fibromyalgia research.

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Comments

  1. Margaret says:

    Thank you for this informative article, Donna. I cross-referenced my 23andme report (the raw data section), and my CRP (rs1205) is genotype C/C, and my PTPN11 (rs2301756) is genotype A/A. If I’m interpreting the data correctly, these are the variants associated with an increased risk of fibromyalgia, which I’ve had for 26 years. Below is a link where you can see other significant polymorphisms (though less significant than CRP and PTPN11). Each time I read a study that is successfully connecting the dots, I feel a happy surge of adrenaline (and I’ve got buckets of adrenaline, because I’m homozygous for two of the main “bad” COMT mutations, which are involved with catecholamine breakdown, which was referenced above). One day, there will be answers, and hopefully sooner than later. Much appreciation to the researchers who are cracking the genetic code, and the enigma that is fibromyalgia.

    http://www.painmed.org/2016posters/abstract-106/

  2. Kathy Carre says:

    Thanks for sharing this, Donna. I will post it on to our page.

    Kathy

    Speaking the truth about Fibromyalgia

    • Donna Gregory/FedUpwithFatigue.com says:

      Thanks for sharing, Kathy! I really appreciate the exposure!

  3. Sandy says:

    Cheaper to have your DNA done by 23andme.

    • Donna Gregory/FedUpwithFatigue.com says:

      23andme and Proove test different things, so I think some patients/doctors would find both helpful.

  4. Michelle Alvarez says:

    I absolutely think there is a genetic component to fms. My grandmother was constantly going to doctors and was told she was a hypochondriac. She died when I was a small child from cirrhosis of the liver and never drank a day in her life. She took massive amounts of over the counter pain relievers and Bella Donna. I also recognize minor fms symptoms in many family members, (sisters and mother) but so far I’m the only lucky fibro loser.

    • Donna Gregory/FedUpwithFatigue.com says:

      I definitely think it’s genetic. My mom had it and now I do.

  5. Jean Harris says:

    Hello, I am quite excited about what I have read about Prove Fibromyalgia Profile. Thanks for understanding that medicinal treatments need to be based on many factors including the fact that each person’s metabolic rates vary. I was diagnosed with fibromyalgia in 2012. I have tried multiple modalities to treat this chronic pain and fatigue. I would love to get an opportunity to participate in this program, but my fixed income limits my ability to gain access to new treatments that are typically not covered by insurance. Please let me know if there is any way to gain access to Prove Fibromyalgia Profile with out paying $799. I live in Gallatin TN which is about 30-40 minutes from NashvilleTN.

    • Donna Gregory/FedUpwithFatigue.com says:

      Please contact Proove. There’s a link at the end of the post. They have options to help people who can’t afford the test.

  6. Linda says:

    All this won’t mean a thing to my Dr.! Keiser!

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